There isnt a known interaction between Injectafer and alcohol. As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. This medication is given by injection into a vein as directed by your doctor. Mild side effects of Injectafer can include:*. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. Venofer (iron sucrose) can also be mixed in a saline solution and given through an IV over a longer time. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. If you have questions about side effects, call your doctor. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. WebMD does not provide medical advice, diagnosis or treatment. Keep in mind that there may be additional costs related to getting your doses of the drug at a medical facility. Tell your doctor about the allergy and what signs you had. Check with your pharmacist if you have questions about the best way to throw out drugs. Other drugs are available that can treat iron deficiency anemia (IDA). This information should not be used to decide whether or not to take Venofer or any other medicine. And the drug has also been studied in children with IDA who have inflammatory bowel disease (IBD). This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. People in the study received treatment with either Injectafer or Venofer. It may also cause nervousness, restlessness, and difficulty sleeping in some people. Copyright 1996-2023 Cerner Multum, Inc. If the underlying cause of your anemia isnt addressed, theres a chance your anemia could come back after Injectafer treatment. Most people do not know how long theirside effectswill last until they go through them. Call your healthcare provider or get medical help right away if you have symptoms of an allergic reaction, including but not limited to rash, chest pain, cough, dizziness, passing out, shortness of breath, sweating or throat tightness. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. Patients should induce vomiting or evacuate the stomach by lavage during Venofer overdoasge. For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. *Patients are calculated based on an estimated annual cumulative dose. . Sharing this information can help you avoid potential interactions. Talk with your doctor. One class of immune checkpoint inhibitors targets the protein PD-1, which acts as a brake to keep the immune system in check. Venofer (iron sucrose) injection, USP is an intravenous (IV) form of iron, which is a key ingredient for making new red blood cells. If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. Selected from data included with permission and copyrighted by First Databank, Inc. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. Youll receive doses of either drug by a healthcare professional at a medical facility. So you wont pick up this medication from a pharmacy. For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Dr. Brandon ColbyMDis a US physician specializingin the personalized prevention of disease through the use of genomic technologies. Hypophosphatemia risk appears to be substantially lower with other IV iron formulations. Do not flush down a toilet or pour down a drain unless you are told to do so. taste impairment. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Serious side effects, which are explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug. If you would like to report to the FDA a side effect youve had with Injectafer, you can do so through MedWatch. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Hemoglobin is a protein thats found inside your red blood cells. Details. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. xmq92\Kz!yIP}2~(?c/JUCK2~o_N=>K$o/_7'Z+nRkKM^y{u|ZFh$v}]O~vfo=.GowGFodVj-[-~x]Kg~9H'%h={OX/#S|Mc~|]_2nv`wwotn/+$G[{hGrP}sbZG-RGf#l~~l|Qnccml_iPy]G\17c,yPF[28z&I'+B(?rrvi,G?}/;'?;pm>?.i42ONmk~ai_u0z9o_? Serious side effects from Injectafer arent common, but they can occur. Injectafer is approved to treat iron deficiency anemia (IDA). In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). Depending on your doctors instructions and
These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). You can also write a reminder on your calendar. I hope you found answers and are feeling better now. Injectafer and Venofer can cause very similar side effects, but some different ones as well. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Notify your healthcare provider of any irritation at the injection site. Its caused by your body not having enough iron, which is needed to make hemoglobin. In Canada - Call your doctor for medical advice about side effects. Venofer® (iron sucrose injection, USP) is available by prescription only. Following an LSD trip, users may experience a sort of 'comedown.'. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. During pregnancy, this medication should be used only when clearly needed. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Its not currently available in generic form. What is the latest research on the form of cancer Jimmy Carter has? Injectafer comes as a liquid solution inside vials. Call your doctor right away if you have serious side effects. With slow IV injection, the drug is given as a single, slow injection into your vein. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. The Injectafer dosage your doctor prescribes will depend on your body weight. In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. Call your doctor for medical advice about side effects. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. If administering via IV infusion, up to 750 mg of Injectafer should be diluted in no more than 250 mL of sterile 0.9% sodium chloride solution (NaCl). Brand-name medications usually cost more than generics. One of the most commonly used tests to monitor IDA is the hemoglobin test. For more information about Injectafers approved uses, see the section Injectafer uses below. So we cant say for sure whether the drug is safe to use while youre pregnant. No, Injectafer itself wont make you gain weight. If you are breastfeeding, tell your doctor if you notice diarrhea or constipation in the nursing baby. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Injectafer and Feraheme have different approved uses, but theyre both used to treat IDA in certain adults. But some people have a delayed allergic reaction to certain drugs. There are different types of anemia, but IDA is the most common type. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. No, you dont need to follow a specific diet plan while youre using Injectafer unless your doctor recommends otherwise. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Your healthcare provider will watch you closely for 30 minutes after each dose. In this study, researchers compared Feraheme treatment with that of ferric carboxymaltose (the active drug in Injectafer). . HRT, like other medications, does have some side effects and these are thought to be quite common. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. However, consuming large amounts of alcohol can actually cause anemia in some people. Call your doctor for medical advice about side effects. Drug interactions may change how your medications work or increase your risk for serious side effects. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Phosphorus also helps your nerves function properly. Together, they can recommend ways to help you manage a body weight thats healthy for you. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Injectafer contains the active drug ferric carboxymaltose. Possibleside effectsareweight gainand suicidal thoughts. These lists dont include all possible side effects. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. Side effectswill last a very long time if the cause of them is not resolved. (And Injectafer is used to treat IDA.) The researchers looked to see how well each drug worked to increase peoples hemoglobin level. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. Additional studies are ongoing to see if Injectafer is a safe and effective treatment option for these conditions. Its responsible for carrying oxygen throughout your body. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. And this could lead to weight gain, if they increase their food intake. The infusion will take between 15-30 minutes if it is given in. These lists contain examples of serious side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). Some may be a better fit for you than others. Injectafer begins working as soon as it enters your body. If you have questions about using Injectafer in a child, talk with your doctor. Boxed warnings alert doctors and patients about drug effects that may be dangerous. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. SIDE EFFECTS: In adult patients, the most common side effects (2%) include diarrhea, upset stomach, throwing up, headache, dizziness, hypotension, pruritus (itching), pain in extremity, arthralgia (joint pain), back pain, muscle cramp, injection site reactions, chest pain and peripheral edema (swelling). For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. Generics tend to cost less than brand-name drugs. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. This can be very helpful in . (A generic drug is an exact copy of the active drug in a brand-name medication.) With CKD, your kidneys dont function properly, which can lead to your body having problems using iron. Youll receive doses of Injectafer from a healthcare professional at a medical facility. Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. For example, some people with anemia have extreme fatigue (lack of energy), which can make it hard for them to exercise. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. For some people, it may be OK to continue taking a multivitamin that contains iron. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Yes, in some cases it may. In the first group, some people continued taking iron by mouth, while other people took Injectafer. Data on file, American Regent, Inc. 1. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. This is why family members often have the same issues with drugs as others in theirfamily. 2 0 obj Most of these side effects may go away within a few days or a couple of weeks. Remember that it is best to get your vitamins and minerals from food whenever possible. Dizziness. Your doctor will determine the best dosage to fit your needs. Without enough hemoglobin, the right amount of oxygen may not reach certain parts of your body. Otherwise, call a poison control center right away. Find comprehensive medical information for Venofer intravenous on RxList including its uses, side effects, precautions, drug interactions, overdose, pill images & warnings . It is important to get each dose of this medication as scheduled. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Before taking Injectafer, be sure to tell your doctor or pharmacist about any medications you take, including any over-the-counter vitamins or supplements. You may also need to monitor your blood pressure at home. Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. This means you would get two Injectafer doses of 720 mg each. fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. These side effects can range from being mild to severe. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Others last much longer (even a lifetime), which can be quite traumatizing to people. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. Best food forward: Are algae the future of sustainable nutrition? Severeside effectsmay end up causing a lot of disruption in a persons life. Limited data indicate that breastmilk iron is not increased after intravenous infusion of Venofer. Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. TheNational Instituteof Health (NIH) and the U.S. Food andDrug Administration(FDA) monitor theside effectsof new and approved medications to ensure safety. Use Venofer as ordered by your doctor. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. No, you wont need to take iron pills while youre using Injectafer. Most mild side effects of Injectafer typically go away within about 30 minutes of receiving your dose of the drug. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. Be ready to tell or show what was taken, how much, and when it happened. Side effectsare uncomfortable reactions to medications or drugs. Your doctor will go over your
Side effects like nausea and low blood pressure are common with most iron infusions. If you have diarrhea while youre taking Injectafer, call your doctor. Injectafer can cause mild or serious side effects. VenAccess is a trademark of Vifor (International) Inc. Switzerland. <> How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. Hypophosphatemia has been reported in people using Injectafer after the drug was released onto the market. They can tell you about other medications that may work well for you. Nose or throat irritation. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Storage Condition Store in a cool and dry place protected from light. People who weigh 110 pounds (about 50 kilograms) or more will receive two separate Injectafer doses of 750 milligrams each. All rights reserved. So theres no recommended pediatric dosage for Injectafer. Venofer also comes as a liquid thats given by either IV infusion or a slow IV injection. Or your doctor may recommend that you change your eating habits to include more iron in your diet. administered at your doctors office or an infusion center. And this would give you a total cumulative Injectafer dose of 1,440 mg. Injectafer should be given in two doses. In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. Tell all of your health care providers that you take Venofer. If these effects continue or worsen, tell your doctor. (A class of medications describes a group of drugs that work in the same way.). These nutrients include iron, vitamin B12, and folate. Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. Iron sucrose can also be mixed in a. For reasons we dont fully understand, some peoples immune system gets over-activated when the drug enters their body. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. Not all possible drug interactions are listed here. Talk with the doctor. Medically reviewed by Sanjai Sinha, MD. The drug helps increase your hemoglobin level back to a value thats within the normal range. Nausea. Do not start, stop, or change the dose of any drug without checking with your doctor. Last updated August 20, 2020. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. Keep all regular medical and laboratory appointments. Why is the range so wide? With anemia, you have a low level of red blood cells (RBCs) in your body. Back pain. In severe cases, it can cause asthma-like symptoms, such as wheezing and difficulty breathing. There are currently no generic forms of either drug. This may be helped by giving the medication more slowly or at a lower dose. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. This survey is being conducted by the WebMD marketing sciences department. Iron infusion benefits. The potential side effects of Daxxify are nearly identical to that of Botox bruising, headaches, and droopy eyelids with one big difference: They could last longer. Consult the product instructions and your pharmacist for storage details. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. Injectafer can be exposed to temperatures between 59F to 86F (15C to 30F) for a short period of time. With IDA, you have low hemoglobin levels. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Venofer may reduce the absorption of iron preparations taken by mouth. And Feraheme is approved for use in adults who have CKD who may or may not need dialysis. I had Venofer infusions, 2 rounds now in the span of three years. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. The way thatprescription drugsand evenover-the-countermedications interact with a body is influenced by manyfactors. Does Venofer Vial interact with other medications? Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Procedure Details generalized weakness. dizziness. Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. Can poor sleep impact your weight loss goals? Available for Android and iOS devices. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Many patients with kidney disease cannot get enough iron from food and require injections. In the study, peoples hemoglobin level was measured to check for improvement in their anemia. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: He said sometimes the reaction does show up after a few doses and unfortunately it takes longer to get over it.